Investigator Initiated Research (IIR) Program

Investigator Initiated Research (IIR) Program


As a part of our commitment to discover, develop, and deliver medicines to the patients who depend on us, we believe in supporting investigator-initiated research (IIR) to advance medical and scientific knowledge in our research areas of interest.

We define IIR as unsolicited research conceived, initiated, and conducted independently of Ionis. An external investigator serves as the sponsor, and with their institution, is wholly responsible for the design, implementation, conduct of the research, data collection, data interpretation, publication, and all compliance, quality, and regulatory requirements.

IIR proposals are evaluated on scientific merit, alignment with our research areas of interest, and availability of resources. Submission of a proposal does not guarantee Ionis’ support.

Research Areas of Interest


  • Specific aspects of Severe Hypertriglyceridemia (sHTG) and Familial Chylomicronemia Syndrome (FCS) Disease, including:
    • Diagnosis and recognition of disease
    • Burden of disease
    • Unmet needs
    • Health economics
    • Patient experience
  • Exploring the effects of sHTG and ApoC-III on the Cardiovascular and Endocrine Systems
  • Mode of action, potential pleiotropic effects, and biochemical pathways of ApoC-III regulation
How to submit an IIR grant application

Please submit grant proposal applications through our online Ionis Research Grants portal by clicking here: Apply Now. If a proposal is of interest, a request for full protocol submission and detailed budget will be issued to enable final review.

The IIR proposal application will request the following details for submission:

  • Research Study Title
  • Background, Clinical Significance, and Rationale
  • Specific Aims/Objectives
  • Study Design
  • Study Endpoints (Specify Primary, Secondary, and Exploratory)
  • Safety Consideration
  • Statistical Methodology
  • Estimated Study Duration
  • Potential Pitfalls and Contingencies
  • References
  • Estimated Total Study Budget
  • Publication Plan
  • Investigator’s CV and Medical License
Contact Information

If you have any questions regarding the Ionis IIR Grant program, please email [email protected]

For Technical Support with the Ionis IIR Portal, please contact SteepRock Client Services via email at [email protected] or phone at +1 (718) 576-1406 (M-F 8am – 6pm US ET).

MED-US-2300825 v2 5/2024

You are now leaving to visit